Aim: To study the effect of testosterone undecanoate (TU) injection on spermatogenesis in rats. Methods: Twenty adult SD rats received vehicle or TU (8 mg/kg, 19 mg/kg or 625 mg/kg) injection, im, every 15 days for 60 days, and another 38 animals received similar treatments for 130 days with half of them undergoing a recovery phase of 120 days (5 rats for each treatment).

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Testosterone Undecanoate Cycle Guide - Steroid Cycles

Introduction. Since the discovery and first clinical use of testosterone in the 1930s, its minimal oral bioavailability has led to administration via every non-oral route to circumvent rapid gut and liver metabolism (). Since the 1950s, the most common route of administration has been the parenteral injection of testosterone as a pro-drug esterified to short-chain aliphatic fatty acids in a .

Testosterone undecanoate: a useful tool for testosterone . - PubMed

Complete suppression of the production of sperm in rats with dienogest (DNG, 40 mg/kg body weight [bw]) plus testosterone undecanoate (TU, 25 mg/kg bw), every 45 days, was found to be associated with a significant increase in germ cell apoptosis. Caspase 3 activity and expression in testis were simultaneously upregulated.

Nandrolone decanoate and testosterone undecanoate differently affect .

In conclusion, a single injection of TUD (100 mg/kg body weight s. c. ) is effective in inducing physiological testosterone levels in ORX rats for a minimum of four weeks. High dose TUD (500 mg/kg body weight i. m. ) given as a single injection results in supraphysiological anabolic testosterone concentrations for up to six weeks in non-ORX rats.

Comparative application of testosterone undecanoate and/or . - PLOS

Testosterone undecanoate (T undecanoate), mentioned as having favorable pharmacokinetics in the Development of methods of male contraception by world health organization . In injection cycle substudy, we administered exogenous testosterone to castrated rats at intervals of 1-4 weeks, using the concentration determined in the dosage substudy

The effects of testosterone replacement on penile structure and .

Castrated rats were treated with testosterone undecanoate for 8 weeks. Based on blood testosterone measurement using enzyme-linked immunosorbent assay, the blood testosterone level was .

Testosterone undecanoate: Uses, Interactions, Mechanism of Action .

The present study investigated and compared the impact of nandrolone decanoate and testosterone undecanoate on body weight gain, levels of stress hormones, brain gene expression, and behavioral profiles in the male rat. The behavioral profile was determined using the multivariate concentric squared field test (MCSF-test).

Comparative application of testosterone undecanoate and/or . - PubMed

Testosterone undecanoate (TU) is under phase III clinical trial as a hormonal male contraceptive in China. Sex hormones can modulate the immune system. Female hormonal contraceptives may affect SIV/HIV-1 transmission. . adult male rats were treated for a 32-week TU-treated phase at the dose of 20 mg TU/kg body weight and a 24-week recovery .

Nandrolone decanoate and testosterone undecanoate differently affect .

Testosterone undecanoate (TU), either dissolved in arachis oil or as micro-crystal suspension, displays androgenic activity on oral administration to rats in the Hershberger test. The solution in arachis oil is more active than the crystal suspension. When [3H]TU is administered orally to rats, most of it is metabolized in the intestinal wall.

Testosterone improved erectile function by upregulating . - Nature

Testosterone undecanoate: a useful tool for testosterone administration in rats Exp Clin Endocrinol Diabetes. 2003 Jun . In conclusion, a single injection of TUD (100 mg/kg body weight s. c. ) is effective in inducing physiological testosterone levels in ORX rats for a minimum of four weeks. High dose TUD (500 mg/kg body weight i. m. ) given as a .

Development and Comparison of Intramuscularly Injected Long-acting .

In conclusion, a single injection of TUD (100 mg/kg body weight s. c. ) is effective in inducing physiological testosterone levels in ORX rats for a minimum of four weeks. High dose TUD (500 mg/kg body weight i. m. ) given as a single injection results in supraphysiological anabolic testosterone concentrations for up to six weeks in non-ORX rats.

Testosterone undecanoate: a useful tool for testosterone administration .

Testosterone undecanoate is a hormone agent with long-acting potential and is used for testosterone replacement therapy for hypogonadism. This study was designed to investigate application of testosterone undecanoate in maintaining high androgen levels for inducing benign prostatic hyperplasia more conveniently than that for testosterone propionate.

Comparative application of testosterone undecanoate and/or testosterone .

Treating rats with testosterone undecanoate associated with moderate physical training for 4 weeks promoted gain in weight (p <0. 01), which was absent in animals treated with TU but not subjected to the exercise program. Similarly, no significant weight gain was observed in the group which underwent training for 4 weeks without TU.

Testosterone undecanoate: a useful tool for testosterone administration .

We used testosterone undecanoate in a dose of 100 mg/kg, since it has been shown that this concentration maintains physiological level of testosterone in male rats for a minimum of four weeks [33 .

Optimal injection interval for testosterone undecanoate treatment of .

A single injection of TUD is effective in inducing physiological testosterone levels in ORX rats for a minimum of four weeks and results in supraphysiological anabolic testosterone concentrations for up to six weeks in non-ORX rats. A major obstacle of testosterone (T) treatment in experimental animals is the difficulty of maintaining long-term physiologic/anabolic steady serum levels after .

Reversible effect of testosterone undecanoate injection on .

Rats were housed under standard conditions (Room temperature 23°C±2°C on 12 h-light/dark cycles at 55%±5% relative humidity and 2 air change cycles/h) and ad libitum to standard rodent chow and filtered water. All rats were grown and kept in cages in the same condition up to 6 months without exposure to any experiments, stress or birth [20,21].

Comparative application of testosterone undecanoate and/or testosterone propionate in induction of benign prostatic hyperplasia in Wistar rats

The rats were administered with normal saline (NS) containing nano-/microcrystals suspensions or commercial testosterone undecanoate injection by i. m. injection (25mg/kg). Blood samples were collected from orbital veins of rats at fix times and centrifuged at 3500 rpm for 10 min.

Testosterone Undecanoate: A Useful Tool for Testosterone . - ResearchGate

Testosterone undecanoate is the ester prodrug of testosterone and has a mid-chain fatty acid at the carbon 17β position. 6 It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone. 2 There are oral and intramuscular formulations . The subcutaneous LD 50 is 2880 mg/kg in mice and rats. 9.

Complete Sperm Suppression in Rats With Dienogest Plus Testosterone .

Interestingly, rats exposed to nandrolone decanoate also demonstrated reduced weight gain in comparison both to the control and rats treated with testosterone undecanoate. The impact of nandrolone on body weight is previously known [36] , [37] , and in fact Lindblom et al. , suggest that the reduced body weight in animals receiving nandrolone .

Effects of administering testosterone undecanoate in rats . - SciELO

Testosterone undecanoate is a form of testosterone steroid containing a larger ester (undecanoate) than many other types. It is available in both oral and injectable forms, and there are different brand names for each. The oral form of testosterone undecanoate is called Andriol, while the brand name of injectable Testosterone undecanoate is .

The pharmacology and metabolism of testosterone undecanoate . - PubMed

These effects were rescued by testosterone undecanoate injection. Erectile function was normalized over 4 weeks in rats that received androgen replacement. . This would allow humans to sustain .

The impact of exogenous testosterone supplementation on spermatogenesis .

Testosterone undecanoate (T undecanoate), mentioned as having favorable pharmacoki- . Rats in the administration group were castrated and administered a single subcutaneous injection of T undecanoate or T propionate at concentrations of 125, 250, 500, 750, or 1000 mg/kg body weight (b. wt) after their operation. .

Effects of testosterone undecanoate as a male contraceptive . - PubMed

And then, testosterone undecanoate was administered at the optimal dose at intervals of 1, 2, 3, or 4 weeks for 12weeks to induce benign prostatic hyperplasia. . In injection cycle substudy, we administered exogenous testosterone to castrated rats at intervals of 1-4 weeks, using the concentration determined in the dosage substudy. T .

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